Fasting for Skin Longevity: How Clarivine™ is Redefining Glass Skin

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• A Scientific Leap: Fasting-Mimicking Applied to Skin Cells
• Unlocking the Potential of Exosomic Delivery
• A Hero Ingredient for Formulators

Fasting has emerged as a scientifically validated physiological practice with growing interest due to its broad-spectrum benefits on health and longevity. Accumulating evidence supports its role in mitigating age-related dysfunction by modulating key metabolic and regenerative processes. In particular, fasting has demonstrated the ability to improve ageing biomarkers, enhance the activation of progenitor and stem cell populations, reduce systemic inflammation, and promote tissue regeneration. These effects position fasting as a potent biological mechanism for cellular protection, damage repair, and resilience enhancement.

Rather than a transient wellness trend, fasting is an evolutionarily conserved survival strategy rooted in natural biology. Throughout human history, fluctuating food availability shaped our metabolic responses, leading to the development of adaptive mechanisms that not only enable survival during periods of scarcity but also confer regenerative advantages. This adaptive physiology has inspired novel therapeutic and cosmetic applications that mimic the fasting state at the cellular level.

In this context, Vytrus Biotech introduces the fasting-mimicking approach as an innovative cosmetic strategy to support skin health, resilience, and longevity. The concept of skin longevity has expanded beyond traditional anti-ageing perspectives to encompass the modulation of biological age, with the goal of maintaining functional and aesthetic integrity over time.

Fasting, particularly in the form of intermittent fasting and caloric restriction, has been shown to modulate key pathways associated with cellular maintenance and lifespan extension. These include the downregulation of insulin/IGF-1 signaling, enhancement of DNA repair capacity, activation of autophagy, suppression of chronic inflammation, and preservation of telomere length. By translating these insights into the field of dermocosmetics, the fasting-mimetic paradigm opens a new frontier in skin regeneration and rejuvenation.

This unique ingredient has already earned global acclaim. Clarivine™ was honoured with Best Innovation Awards at both in-cosmetics Global 2025 and Indonesia Cosmetic Ingredients 2025, while also being recently granted a U.S. patent for its wound-healing potential. These achievements mark Clarivine™ as a true scientific milestone in skin longevity and plant biotechnology.

As L'Oréal CEO Nicolas Hieronimus recently emphasized, the future of beauty lies in longevity—not just masking age but promoting healthspan and biological vitality. In line with this vision, Clarivine™ represents a next-generation cosmetic active that brings cutting-edge longevity science into everyday skincare 

A Scientific Leap: Fasting-Mimicking Applied to Skin Cells

Through a patented and controlled nutrient deprivation process, Vytrus induces a hormetic response in the plant cells—a beneficial mild stress that activates survival and repair mechanisms. This stress leads to the production of a sophisticated and potent Fasting-Mimicking Secretome rich in bioactive compounds known as Plant Fasting Factors. 

Clarivine™ is a 100% natural biotechnological active derived from Vitis vinifera stem cells. Inspired by the benefits of fasting, Clarivine™ activates key skin pathways that promote cellular detoxification, renewal, and protection, achieving a glass skin effect while prolonging skin cellular longevity.

Its unique fasting-mimicking effect stimulates the skin’s natural resilience by:

• Activating autophagy to remove cellular waste and improve clarity.
• Protecting telomeres, preserving cellular integrity to delay aging.
• Neutralizing oxidative stress, strengthening the skin’s defenses.
• Reducing ageing pigments accumulation, for a brighter, even complexion.

Plant Fasting Factors Encapsulated in Exosomes

Vytrus’ innovative biotechnology subjects grapevine stem cells to controlled nutrient deprivation, triggering a hormetic response to a positive mild stress that produces a bioactive secretome packed with:

• Polyphenols and secondary metabolites - Antioxidants that increase skin longevity.
• Signaling peptides and proteins - Regenerating and strengthening the skin.
• Natural plant exosomes rich in exosomic peptides and resveratrol - A precision natural delivery system that optimizes cell communication and ingredient absorption.

Key Benefits

Clarivine™ delivers a multitargeted solution for skin longevity by:

• Stimulating the skin’s natural detox and renewal processes through autophagy
• Reducing visible signs of ageing, including fine lines and age spots
• Brightening and evening skin tone by reducing melanin and lipofuscin accumulation (age-related pigments)
• Reinforcing the skin barrier for improved resilience and hydration
• Enhancing cellular vitality via telomere protection and oxidative stress defense

Clinical Study Results

Clarivine™ has been clinically validated across multi-ethnic panels (Caucasian & Asian volunteers), showing marked improvements in skin quality through a scientifically proven longevity approach.

In just 14 days , Clarivine™ has demonstrated significant improvements in skin hydration and wrinkles’ appearance — delivering the highly sought-after glass skin effect through a scientifically proven longevity approach.

Notably, Vytrus Biotech is the first company to demonstrate the fasting-mimicking effect in vivo, establishing a validated mechanism of action. Additionally, Clarivine™ significantly enhanced the skin's antioxidant potential, helping protect against oxidative damage and supporting long-term skin vitality at a cellular level.

The ingredient was also tested on an Asian volunteer panel, showing marked improvements in radiance, pigmentation and texture improvement. These consistent results across ethnicities reinforce Clarivine™'s versatility and broad-spectrum efficacy.

The Caucasian volunteer panel also demonstrated brighter, more even complexions and a visibly smoother skin texture and mosturization. These outcomes reflect Clarivine™'s ability to act on key markers of skin ageing while supporting the skin’s own regenerative capacity.

Unlocking the Potential of Exosomic Delivery

What truly distinguishes Clarivine™ is its exosomic potential. The bioactives produced during the fasting-mimicking process are not simply mixed into a formula—they are naturally encapsulated in plant exosomes. These nanoscale vesicles act as targeted transporters, delivering their molecular cargo directly into skin cells where they are most effective.

What truly distinguishes Clarivine™ is its exosomic architecture. The bioactives produced during the fasting-mimicking process are not simply mixed into a formula—they are naturally encapsulated in plant exosomes. These nanoscale vesicles act as targeted transporters, delivering their molecular cargo directly into skin cells where they are most effective.

Exosomes derived from Vitis vinifera are packed with:

• Exosomic resveratrol: A grape-derived antioxidant that not only protects cells from oxidative damage but also acts as a signaling molecule that activates the same longevity pathways triggered during fasting.
• Exosomic peptides: a great diversity of natural plant peptides that encourage regeneration, improve elasticity, and optimize skin's resilience.

This mechanism of cross-kingdom communication allows plant-derived molecules to trigger specific responses in human skin cells, setting a new benchmark for precision in cosmetic biotechnology.

A Hero Ingredient for Formulators

Clarivine™ introduces a new paradigm in the skin longevity and dermocosmetic fields—marking a scientific leap in cellular rejuvenation inspired by fasting biology. 

As an efficient and sustainable active ingredient,  Clarivine™ meets the high standards of Vytrus Biotech innovations for cosmetic formulators: 100% natural origin, COSMOS-approved, China compliant, Halal certified, microbiome compatible and preservative free.

This next-generation, plant biotechnology-based active opens formulators novel pathways for promoting skin resilience and radiance, offering a sustainable and high-efficacy solution that supports both immediate glass skin effect and long-term biological renewal:

• Well-ageing & skin repair formulations
• Longevity enhancement & skin detox treatments
• Brightening / radiance / luminosity-enhancing products
• Anti-pigmentation, dark spot reduction & uniforming routines
• Hydration boosting formulations
• Exosome, peptide & resveratrol claims in cosmetic products
• Skin refinement, and tone & texture improvement formulations 

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The views expressed in this article are those of the author and do not necessarily reflect the views of Covalo.