Unlocking Skin’s Lifespan: The Power of Plant-Based Stem Cells

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• Plant Stem Cells in Skincare vs Human stem cells
• What is the influence of plant stem cells on the skin microbiome?
• Techniques for Producing Plant Stem Cells in Cosmetics 
• Why plant stem cells are important to support longevity
• My favorite manufacturers and suppliers of plant stem cells

We have partnered with Jelena Simić, celebrated cosmetic chemist and lead formulator at Delicya Ltd. With over three decades of experience crafting wellness-focused beauty solutions, Jelena brings both scientific precision and a deep passion for skin longevity. Her expertise in formulating with plant-based ingredients brings an in-depth insight into creating new products by using the best of nature. 

In recent years, skincare has taken a thoughtful turn toward embracing the natural process of aging rather than fighting against it. Thus, we should explore the promising role of plant-derived stem cells in supporting skin longevity, healthy aging, and a balanced skin microbiome. With a focus on slow-aging, the modern approach celebrates maturity as a privilege—not a problem to be fixed. The spotlight is on developing microbiome-friendly products that work in harmony with the skin, helping to smooth wrinkles, soothe irritation and inflammation, reduce the appearance of fine lines and sagging, and improve overall complexion. At its core, this philosophy champions the belief that healthy skin is beautiful skin.

Continue reading to explore how plant stem cells support skin’s longevity.

Plant Stem Cells in Skincare vs Human stem cells

Plant stem cells are derived from various plant species and are known for their regenerative properties. These stem cells are rich in antioxidants, peptides, and growth factors, which are responsible for rejuvenating skin cells, repairing damage, and promoting tissue regeneration. Their ability to stimulate cellular turnover and boost collagen production makes them highly appreciated as wonderful ingredients in every formulation with the main purpose to slow down the aging process, aiming to reduce visible wrinkles, fine lines, and sagging skin. 

As a standout example, we have ALGAKTIV® Exometics G, a brand new biomimetic exosome created from microalgae. Through its advanced technology, it rejuvenates the skin by fading dark spots, and boosting skin smoothness. 

Human stem cells are not typically used directly in cosmetics

While stem cell research is promising for skin rejuvenation, using actual human stem cells in cosmetic products is generally not permitted or practical, for various reasons, including ethical sourcing. Although they are considered as an invaluable source in medicine for treating disease, many types of human stem cells are still in the research phase. Clinical trials are ongoing to evaluate the safety and effectiveness of stem cell therapies.

What is the influence of plant stem cells on the skin microbiome?

The skin’s microbiome plays a vital role in maintaining its health and barrier function. Disruptions in this delicate ecosystem can lead to conditions such as acne, eczema, and other inflammatory skin issues. Plant stem cells are here to support and maintain skin microbiota by reinforcing the skin’s natural barrier, and boosting the growth of useful microorganisms. Balancing the pH, enhancing the skin’s natural defenses helps prevent harmful bacteria from growing and holding tight.

For this purpose, let’s explore different types of plant stem cells, and their benefits.

Apple Stem Cells (Malus Domestica)

Derived from the rare Uttwiler Spätlauber apple, known for its ability to regenerate and preserve itself in extreme climates. These stem cells are rich in longevity-promoting compounds, including antioxidants, proteins, polyphenols and many others. These growth factors help protect skin cells from oxidative stress, environmental damage, promote collagens, stimulate elastin production, responsible for protecting skin barrier, repairing skin complexion.

PhytoCellTec™ Malus Domestica by Mibelle Biochemistry is the perfect example of this plant cell usage. Through its patented liposomal preparation, this ingredient is rich in epigenetic factors and metabolites, for longevity of skin cells. 

Orange Stem Cells (Citrus Sinensis)

Stem cells extracted from oranges, particularly the bitter orange (Citrus aurantium), offer potent antioxidant protection against environmental stressors like UV radiation and pollution. They help promote collagen synthesis and protect the skin from aging caused by free radicals, especially in these modern times, where we are exposed to blue light, constantly in a hurry, working during night, our skin suffers a lot. 

Extrinsic aging is higher than ever. Food, air, surroundings, all of that have a huge impact on us. We need to adapt to various climate zones while travelling. That is why choosing stem cells in the formulations for our nourishing regimen, skincare routine is on the rise.

Grape Vine Stem Cells (Vitis Vinifera)

Grape stem cells are derived from the seeds and skins of grapes, from the vigorous varieties grown in the Mediterranean. Rich in polyphenols, including resveratrol, these stem cells are known for their anti-aging properties, enhancing skin’s firmness, elasticity, and radiance. They are also known to stimulate cellular regeneration and fight free radical damage. This fruit is so complex, it deserves a special place.There is one very interesting story about grapes, ice cream and wine. Stay tuned as I will reveal interesting facts in my third article in this series! 

For example, Clarivine™ by Vytrus Biotech uses this active to mimic the benefits of intermittent fasting on the skin at a cellular level. This improves longevity markers and activates the skin’s natural regeneration processes.  

Argan Tree Stem Cells (Argania Spinosa)

Extracted from the Argan tree, which is native to Morocco, these stem cells contain essential fatty acids and antioxidants. They help improve skin hydration, reduce fine lines, and boost skin resilience against oxidative damage, giving moisture and plumping looking skin.

Lotus Stem Cells (Nelumbo Nucifera)

Known for their soothing and anti-inflammatory effects, lotus stem cells are used in skincare to aid skin regeneration and improve elasticity. They also help with balancing the skin's moisture levels.

Techniques for Producing Plant Stem Cells in Cosmetics 

The most common methods for harvesting cultivating plant stem cells involve tissue culture techniques, where small sections of plant tissue are grown in controlled environments. The two primary methods are callus culture and suspension culture. These stem cells are then concentrated and incorporated into skincare formulations.

Incorporation into Skincare Formulas

Plant stem cells are typically integrated into skincare products through advanced delivery systems, such as encapsulation in liposomes or microemulsions. These systems protect the stem cells during application and enhance their absorption by the skin. Stem cells can penetrate the epidermis to stimulate cell regeneration and provide anti-aging benefits.

Why plant stem cells are important to support longevity

Plant stem cells offer several compelling benefits in skincare, particularly for aging skin. They help stimulate collagen and elastin production—key components for maintaining firmness and elasticity. Rich in antioxidants, these stem cells also defend against environmental stressors such as UV rays and pollution, helping to minimize their aging effects. Additionally, they support skin regeneration and cellular repair, promoting a more youthful, revitalized appearance. Importantly, plant stem cells also nurture the skin’s natural microbiome, fostering a balanced and resilient skin barrier that helps prevent premature aging and inflammation.

While these benefits are promising, challenges remain, such as ensuring consistent quality and potency of stem cell extracts in formulations. Additionally, further studies are needed to fully understand the long-term effects of plant stem cells on skin health, including their precise mechanisms of action and efficacy across diverse skin types.

As consumers grow more mindful of both their health and their environmental impact, the personal care industry is evolving—embracing smarter, more sustainable approaches. At the intersection of longevity science, plant biotechnology, and eco-conscious beauty, plant-derived stem cells have emerged as powerful botanical actives. Not only do they play a vital role in promoting slow-aging and supporting skin health; they also contribute to the broader goal of environmental sustainability. These innovative ingredients represent a shift toward a more holistic, forward-thinking approach to beauty—one that values both personal well-being and the planet’s longevity.

My favorite manufacturers and suppliers of plant stem cells

Several companies specialize in producing plant stem cell extracts for the skincare industry, ensuring that these ingredients are high-quality and safe for use in cosmetic formulations:

1. Mibelle Biochemistry (Switzerland) – Known for their PhytoCellTec technology, which provides various plant stem cell extracts, including apple, grapevine, and argan.
2. BASF (Germany) – Offers plant-based stem cell extracts through their Lumicell and Plant-Repair product lines, targeting skin regeneration and protection.
3. Exsymol (Monaco) – Develops advanced plant stem cell solutions for anti-aging, including Peptide Stem Cells and Argania Stem Cells
4. HaptaCell by HaptaTech (USA) - Specializes in natural plant stem cells, including those from lotus and grapevine, for enhanced cellular regeneration.
5. Givaudan Active Beauty (Switzerland) – Offers a variety of plant stem cells like Apple Stem Cell Extract and Vineyard Cell to support slow-aging and skin rejuvenation.
6. Provital, Do Care (Spain) – Through their "Provital Stem Cells Collection", they offer a series of biotechnological products from different botanical sources. 
7. Vytrus Biotech (Spain) – An innovative Spanish company specialized in developing, producting and commercializing high added value and 100% natural active ingredients based on plant biotechnology for skin and hair care.

Learn more about Longevity suppliers and their hero ingredients on Covalo!

The views expressed in this article are those of the author and do not necessarily reflect the views of Covalo.